en <span style="font-size:11pt"><span style="line-height:normal"><span style="tab-stops:0cm"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="EN" style="font-size:10.0pt"><span style="font-family:&quot;Cambria&quot;,serif"><span style="color:#f79646">Aims:</span></span></span></b> <span style="font-size:10.0pt"><span style="font-family:&quot;Cambria&quot;,serif">Lymphoid malignancies are increasingly prevalent in Iraq, where chemotherapy remains the principal treatment despite its association with oxidative stress. This study investigated the impact of chemotherapy on serum levels of antioxidant vitamins C, E, and D3 in patients with lymphoma.</span></span><span style="font-size:10.0pt"><span style="font-family:&quot;Cambria&quot;,serif"></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="tab-stops:0cm"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="EN" style="font-size:10.0pt"><span style="font-family:&quot;Cambria&quot;,serif"><span style="color:#f79646">Materials & Methods</span></span></span></b><b><span lang="EN" style="font-size:10.0pt"><span style="font-family:&quot;Cambria&quot;,serif"><span style="color:#f79646">:</span></span></span></b> <span style="font-size:10.0pt"><span style="font-family:&quot;Cambria&quot;,serif">This case-control study was conducted involving 120 individuals divided into three groups, including healthy controls (n=40), newly diagnosed untreated lymphoma patients (n=40), and lymphoma patients undergoing chemotherapy (n=40). Serum levels of vitamins C, E, and D3 were measured using ELISA, and statistical analysis was performed using ANOVA followed by Tukey&rsquo;s post hoc analysis. The diagnostic potential was assessed through receiver operating characteristic curve analysis.</span></span><span style="font-size:10.0pt"><span style="font-family:&quot;Cambria&quot;,serif"></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="tab-stops:0cm"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="EN" style="font-size:10.0pt"><span style="font-family:&quot;Cambria&quot;,serif"><span style="color:#f79646">Findings:</span></span></span></b> <span style="font-size:10.0pt"><span style="font-family:&quot;Cambria&quot;,serif">All lymphoma patients exhibited significantly reduced serum concentrations of vitamins C, E, and D3 compared to controls (p<0.0001). Chemotherapy-treated patients showed partial recovery in these levels, although the values remained below normal. Receiver operating characteristic analysis revealed strong discriminatory power for all three vitamins, especially vitamin D3, which emerged as a promising biomarker for disease presence and treatment monitoring.</span></span><span style="font-size:10.0pt"><span style="font-family:&quot;Cambria&quot;,serif"></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="tab-stops:0cm"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="EN" style="font-size:10.0pt"><span style="font-family:&quot;Cambria&quot;,serif"><span style="color:#f79646">Conclusion:</span></span></span></b> <span style="font-size:10.0pt"><span style="font-family:&quot;Cambria&quot;,serif">Chemotherapy in lymphoma patients leads to partial improvement, but not normalization, of antioxidant vitamin levels.</span></span></span></span></span></span></span> Antioxidants,Vitamins,Oxidative Stress,Lymphoma, 191 196 http://ijwph.ir/browse.php?a_code=A-10-2325-1&slc_lang=en&sid=3 F.J.H. Alhnon 1003194753284600379601 1003194753284600379601 Yes Department of Chemistry, College of Science, Al-Nahrain University, Baghdad, Iraq F.A. Hassan 1003194753284600379600 1003194753284600379600 No Department of Chemistry, College of Science, Al-Nahrain University, Baghdad, Iraq