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en Comfort Level in Hemodialysis Patients and Its Relationship with Symptom Burden Aims: Patients with renal failure face challenges that severely hinder their independence and limit various aspects of their daily lives. Therefore, this study aimed to assess the comfort level of hemodialysis patients and its relationship with symptom burden. Instrument & Methods: This descriptive cross-sectional study using a purposive sampling method was performed on 257 dialysis patients from six hemodialysis centers. The Chronic Kidney Disease Symptom Burden Index (CKD-SBI) and the Hemodialysis Comfort Questionnaire were used to collect data from October 28, 2024, to June 7, 2025. The Spearman’s rho correlation, Mann-Whitney U-Test, and Kruskal-Wallis Test were employed to analyze data using SPSS 26. Findings: The mean age of the patients was 38.67 years, and the majority were male and married. Most of their education levels ranged from illiteracy to university education, and more than half (55.6%) suffered from chronic diseases. All patients (100%) had a moderate comfort level, and most (75.1%) experienced moderate symptom burden. There was a significant negative relationship between symptom burden and comfort level among the patients (p=0.01). Conclusion: There is a significant negative relationship between symptom burden and comfort level in dialysis patients. Symptom Burden,Patients,Hemodialysis, 223 228 http://ijwph.daneshafarand.org/browse.php?a_code=A-10-2322-1&slc_lang=en&sid=3 A.R. Qaed 1003194753284600379767 1003194753284600379767 Yes Ministry of Health, Al-Diwaniyah Health Directorate, Al-Diwaniyah, Iraq H.H. Atiyah 1003194753284600379938 1003194753284600379938 No Department of Adult Nursing, College of Nursing, University of Baghdad, Baghdad, Iraq