Aims: Coronavirus Disease-2019, is a rapidly spreading pandemic triggered by a new human coronavirus. It was the most common dangerous health crisis. The study aimed to assess attitudes regarding COVID-19 among nurses. Instrument & Methods: A descriptive study was carried out to assess nurses’ attitudes regarding COVID-19 in Al-Hilla teaching hospitals at Al-Hilla city from 25th September 2020 to 20February 2022. A convenient non-probability sample was selected for 200 nurses who are working at epidemic hospitals. A questionnaire was comprised of two parts; demographical data, and the items related to nurses' attitudes about COVID-19. The data were analyzed by one-way ANOVA using SPSS 25, and Microsoft Excel 2010. were performed in assessing any difference in mean knowledge score by demographic characteristics. Findings: The findings showed through the analysis of attitudes towards COVID-19 demonstrated that the majority of nurses (86%) expressed a positive attitude towards COVID-19, which illustrated the nurses had psychological attention to overcoming the covid-19 pandemic, there were important variances in the attitudes regarding COVID-(p<0.05) in related to nurses' ages, there were significant differences between nurses' about COVID-19 (p<0.05), concerning nurses' educational levels and displays that there were significant differences between nurses' attitudes regarding COVID-19 (p<0.05) with the working years in nursing. Conclusion: Nurses expressed positive attitudes towards COVID-19. Nurses' attitudes toward COVID-19 had significant differences regarding the variables such as Nurses' age, education level, and years of experience in nursing.