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Volume 14, Issue 2 (2022)
3 2022, 14(2): 217-220 |
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Received: 2022/03/1 | Accepted: 2022/04/28 | Published: 2022/05/30
Received: 2022/03/1 | Accepted: 2022/04/28 | Published: 2022/05/30
How to cite this article
Umran Z, Abbas Hadi A, Mohammad A. Assessment of β-catenin as a Potential Marker for Human Colorectal Carcinoma. 3 2022; 14 (2) :217-220
URL: http://ijwph.daneshafarand.org/article-3-85465-en.html
URL: http://ijwph.daneshafarand.org/article-3-85465-en.html
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1- Department of Laboratory Investigations, Faculty of Science, University of Kufa, Najaf, Iraq
2- Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Kufa, Najaf, Iraq
2- Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Kufa, Najaf, Iraq
Abstract (2012 Views)
Aims: Colorectal cancer was currently the most frequent malignant cancer of the gastrointestinal system, accounting for 13% of all malignant tumors, and it is the second most common cause of death from cancer worldwide. Aim of study was to clarify the relationship between β-catenin levels in sera, some clinical and pathological variables in Colorectal cancer patients, as well as explore the link between this biomarker and disease diagnosis and progression.
Material & Methods: The current study included (55) Colorectal cancer patients and (35) healthy subjects. ELISA was used to calculate serum β-catenin in order to study the relationships between this biomarker and gender, age, histological type, stages, grades, tumor site, and body mass index.
Findings: Results showed a significant increase in the levels of β-catenin of Colorectal cancer patients in comparison with the control group (p<0.05). In parallel, no significant correlations have been found in β-catenin levels with all clinical parameters covered by the study (p>0.05).
Conclusion: β-catenin is a less sensitive marker for Colorectal cancer in the detection and prognosis of the advanced stages of cancer.
Material & Methods: The current study included (55) Colorectal cancer patients and (35) healthy subjects. ELISA was used to calculate serum β-catenin in order to study the relationships between this biomarker and gender, age, histological type, stages, grades, tumor site, and body mass index.
Findings: Results showed a significant increase in the levels of β-catenin of Colorectal cancer patients in comparison with the control group (p<0.05). In parallel, no significant correlations have been found in β-catenin levels with all clinical parameters covered by the study (p>0.05).
Conclusion: β-catenin is a less sensitive marker for Colorectal cancer in the detection and prognosis of the advanced stages of cancer.
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